Description
Recombinant Human Interleukin-17A/IL-17A Protein (Yeast, His Tag)(Active) | PKSH030924 | Gentaur US, UK & Europe Disrtribition
Synonyms: Interleukin-17A; IL-17; IL-17A; Cytotoxic T-Lymphocyte-Associated Antigen 8; CTLA-8; IL17A; CTLA8; IL17
Active Protein: Active protein
Activity: A DNA sequence encoding human IL17A (Q16552) (Gly24-Ala155) was expressed with a polyhistidine tag at the N-terminus.
Protein Construction: A DNA sequence encoding human IL17A (Q16552) (Gly24-Ala155) was expressed with a polyhistidine tag at the N-terminus.
Fusion Tag: N-His
Species: Human
Expressed Host: Yeast
Shipping: This product is provided as lyophilized powder which is shipped with ice packs.
Purity: > 95 % as determined by reducing SDS-PAGE.
Endotoxin: Please contact us for more information.
Stability and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Molecular Mass: 17.3 kDa
Formulation: Lyophilized from sterile PBS, pH 7.4
Reconstitution: Please refer to the printed manual for detailed information.
Background: IL17; also known as IL17a; is a cytokine belongs to the IL-17 family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation; differentiation and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes; macrophages; dendritic cells) and adaptive (T- and B-cells) immune systems. The IL-17 family of cytokines includes six members; IL-17/IL-17A; IL-17B; IL-17C; IL-17D; IL-17E/IL-25; and IL-17F; which are produced by multiple cell types. IL-17 regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2); as well as enhance the production of nitric oxide (NO). High levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis; psoriasis and multiple sclerosis.Immune Checkpoint Immunotherapy Cancer Immunotherapy Targeted Therapy
Research Area: Cancer, immunology
