Recombinant Human IL3RA/CD123 Protein (Fc Tag) | PKSH033617

Recombinant Human IL3RA/CD123 Protein (Fc Tag) | PKSH033617 | Gentaur US, UK & Europe Disrtribition

Synonyms: Interleukin-3 receptor subunit alpha; IL-3 receptor subunit alpha; IL-3R subunit alpha; IL-3R-alpha; IL-3RA

Active Protein: N/A

Activity: Recombinant Human IL3-RA is produced by our Mammalian expression system and the target gene encoding Thr19-Arg305 is expressed with a Fc tag at the C-terminus.

Protein Construction: Recombinant Human IL3-RA is produced by our Mammalian expression system and the target gene encoding Thr19-Arg305 is expressed with a Fc tag at the C-terminus.

Fusion Tag: C-Fc

Species: Human

Expressed Host: Human Cells

Shipping: This product is provided as lyophilized powder which is shipped with ice packs.

Purity: > 95 % as determined by reducing SDS-PAGE.

Endotoxin: < 1.0 EU per μg as determined by the LAL method.

Stability and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Molecular Mass: 59.9 kDa

Formulation: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Reconstitution: Please refer to the printed manual for detailed information.

Background: CD123; also known as Interleukin-3 receptor subunit alpha; belongs to the type I cytokine receptor family. In mouse; there are two classes of high-affinity IL3 receptors. One contains an IL3-specific beta subunit and the other contains the beta subunit also shared by high-affinity IL5 and GM-CSF receptors. CD123 stimulates the proliferation and differentiation of hemopoietic cells including the pluripotent hematopoietic stem cells as well as various lineage-committed cells. CD123 is a heterodimer consisting of an alpha and a beta subunit. The alpha subunit alone binds IL-3 with low affinity. The beta subunit does not bind IL-3 by itself but is required for the high-affinity binding of IL-3 to the heterodimeric receptor complex.

Research Area: Signal Transduction, immunology,