Recombinant Human IL3RA/CD123 Protein (Fc & Avi Tag) | PKSH033800

Recombinant Human IL3RA/CD123 Protein (Fc & Avi Tag) | PKSH033800 | Gentaur US, UK & Europe Disrtribition

Synonyms: Interleukin-3 receptor subunit alpha; IL-3 receptor subunit alpha; IL-3R subunitalpha; IL-3R-alpha; IL-3RA

Active Protein: N/A

Activity: Biotinylated Recombinant Human IL3-RA is produced by our Mammalian expression system and the target gene encoding Thr19-Arg305 is expressed with a Fc; Avi tag at the C-terminus.

Protein Construction: Biotinylated Recombinant Human IL3-RA is produced by our Mammalian expression system and the target gene encoding Thr19-Arg305 is expressed with a Fc; Avi tag at the C-terminus.

Fusion Tag: C-Fc-Avi

Species: Human

Expressed Host: Human Cells

Shipping: This product is provided as lyophilized powder which is shipped with ice packs.

Purity: > 90 % as determined by reducing SDS-PAGE.

Endotoxin: < 1.0 EU per μg as determined by the LAL method.

Stability and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Molecular Mass: 61.8 kDa

Formulation: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Reconstitution: Please refer to the printed manual for detailed information.

Background: CD123; also known as Interleukin-3 receptor subunit alpha; belongs to the type I cytokine receptor family. In mouse; there are two classes of high-affinity IL3 receptors. One contains an IL3-specific beta subunit and the other contains the beta subunit also shared by high-affinity IL5 and GM-CSF receptors. CD123 stimulates the proliferation and differentiation of hemopoietic cells including the pluripotent hematopoietic stem cells as well as various lineage?committed cells. CD123 is a heterodimer consisting of an alpha and a beta subunit. The alpha subunit alone binds IL?3 with low affinity. The beta subunit does not bind IL?3 by itself but is required for the high?affinity binding of IL?3 to the heterodimeric receptor complex.

Research Area: Signal Transduction, immunology,