Recombinant Human IL27Ra/TCCR/WSX1 Protein (Fc Tag)(Active) | PKSH031571

Recombinant Human IL27Ra/TCCR/WSX1 Protein (Fc Tag)(Active) | PKSH031571 | Gentaur US, UK & Europe Disrtribition

Synonyms: CRL1;IL-27RA;IL27R;TCCR;WSX1;zcytor1

Active Protein: Active protein

Activity: A DNA sequence encoding the extracellular domain (Met 1-Arg 514) of human IL27Rα (NP_004834.1) was fused with the Fc region of human IgG1 at the C-terminus.

Protein Construction: A DNA sequence encoding the extracellular domain (Met 1-Arg 514) of human IL27Rα (NP_004834.1) was fused with the Fc region of human IgG1 at the C-terminus.

Fusion Tag: C-Fc

Species: Human

Expressed Host: HEK293 Cells

Shipping: This product is provided as lyophilized powder which is shipped with ice packs.

Purity: > 95 % as determined by reducing SDS-PAGE.

Endotoxin: < 1.0 EU per µg as determined by the LAL method.

Stability and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Molecular Mass: 79 kDa

Formulation: Lyophilized from sterile PBS, pH 7.4, 8% trehalose, 8% mannitol

Reconstitution: Please refer to the printed manual for detailed information.

Background: The interleukin-27 receptor is a type I cytokine receptor for interleukin-27. It is a heterodimer composed of the interleukin 27 receptor, alpha subunit and glycoprotein 130. WSX-1/IL-27R, a class I cytokine receptor that is homologous to the β2 chain of the IL-12R in both sequence and structure, is highly expressed by resting/naive CD4+ T cells and CD8+ T cells. WSX-1/IL-27R belongs to the IL-6/IL-12 family of cytokines and induced proliferation of naive CD4(+) T cells and the generation of a Th1-type adaptive immune response. WSX-1/IL-27R functions as a receptor for IL27. IL-27 not only contributes to the development of an adaptive immune response through its action on CD4(+) T cells, it also directly acts on cells of the innate immune system. WSX-1/IL-27R requires IL6ST/gp130 to mediate signal transduction in response to IL27. This signaling system acts through STAT3 and STAT1. It is involved in the regulation of Th1-type immune responses. IL-27R also appears to be involved in innate defense mechanisms. IL27RA is essential for transcriptional activation of STAT1 and for augmenting the induction of T-bet expression during initiation of Th1 cell differentiation.

Research Area: Signal Transduction, epigenetics and nuclear signal, immunology,