Description
Recombinant Human IL-35 protein(His tag) | PKSH500096 | Gentaur US, UK & Europe Disrtribition
Synonyms: IL-27 subunit beta;IL-27B;Epstein-Barr virus-induced gene 3 protein;EBV-induced gene 3 protein
Active Protein: N/A
Activity: A DNA sequence encoding theHuman IL-35 protein (Q14213&P29459) (Arg21-Lys229&(GGGGS)3&Arg23-Ser219) was expressed with a N-His.
Protein Construction: A DNA sequence encoding theHuman IL-35 protein (Q14213&P29459) (Arg21-Lys229&(GGGGS)3&Arg23-Ser219) was expressed with a N-His.
Fusion Tag: N-His
Species: Human
Expressed Host: E.coli
Shipping: This product is provided as lyophilized powder which is shipped with ice packs.
Purity: > 90 % as determined by reducing SDS-PAGE.
Endotoxin: Please contact us for more information.
Stability and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Molecular Mass: 49.5 kDa
Formulation: Lyophilized from sterile PBS, pH 7.5, 5% trehalose, 5% mannitol, 0.01% tween-80.
Reconstitution: Please refer to the printed manual for detailed information.
Background: Associates with IL27 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity. IL-27 has pro- and anti-inflammatory properties, that can regulate T-helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR. Another important role of IL-27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines.
Research Area: N/A
