Recombinant Human IL-23 Recetor/IL-23R Protein (Fc Tag)(Active) | PKSH032579

Recombinant Human IL-23 Recetor/IL-23R Protein (Fc Tag)(Active) | PKSH032579 | Gentaur US, UK & Europe Disrtribition

Synonyms: Interleukin-23 receptor; IL23R; IL-23 receptor; IL-23R

Active Protein: Active protein

Activity: Recombinant Human Interleukin-23 Receptor is produced by our Mammalian expression system and the target gene encoding Gly24-Asp353 is expressed with a Fc tag at the C-terminus. 

Protein Construction: Recombinant Human Interleukin-23 Receptor is produced by our Mammalian expression system and the target gene encoding Gly24-Asp353 is expressed with a Fc tag at the C-terminus. 

Fusion Tag: C-Fc

Species: Human

Expressed Host: Human Cells

Shipping: This product is provided as lyophilized powder which is shipped with ice packs.

Purity: > 90 % as determined by reducing SDS-PAGE.

Endotoxin: < 1.0 EU per µg as determined by the LAL method.

Stability and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Molecular Mass: 65.0 kDa

Formulation: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Reconstitution: Please refer to the printed manual for detailed information.

Background: Interleukin 23 receptor (IL23R) is a type I cytokine receptor for IL23. IL23 receptor complex is comprised of two subunits; the IL12Rβ1 subunit; which is shared with several cytokines; and a subunit that is unique to IL-23. IL23; after binding to IL23R; activates memory T cells and mediates pro-inflammatory activities in part by the production of IL17 through activation of TH17 lymphocytes. IL23R is expressed on T cells; NK cells; dendritic cells; and macrophages. In fact; polymorphisms of the IL23R gene were reported to be associated with susceptibility to inflammatory diseases and autoimmune diseases such as psoriasis; multiple sclerosis; Graves's ophtalmopathy and inflammatory bowel diseases. The IL23R is known to be critically involved in the carcinogenesis of different malignant tumor.

Research Area: Signal Transduction, epigenetics and nuclear signal, immunology,