Recombinant Human IL-22BP/IL22RA2 Protein (His Tag)(Active) | PKSH031300

Recombinant Human IL-22BP/IL22RA2 Protein (His Tag)(Active) | PKSH031300 | Gentaur US, UK & Europe Disrtribition

Synonyms: CRF2-10;CRF2-S1;CRF2X;IL-22BP;IL-22R-alpha-2;IL-22RA2;ZCYTOR16

Active Protein: Active protein

Activity: A DNA sequence encoding the human IL22RA2 isoform 2 (NP_851826.1) (Met 1-Pro 231) was expressed; fused with a polyhistidine tag at the C-terminus.

Protein Construction: A DNA sequence encoding the human IL22RA2 isoform 2 (NP_851826.1) (Met 1-Pro 231) was expressed; fused with a polyhistidine tag at the C-terminus.

Fusion Tag: C-His

Species: Human

Expressed Host: HEK293 Cells

Shipping: This product is provided as lyophilized powder which is shipped with ice packs.

Purity: > 95 % as determined by reducing SDS-PAGE.

Endotoxin: < 1.0 EU per µg of the protein as determined by the LAL method.

Stability and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Molecular Mass: 26.1 kDa

Formulation: Lyophilized from sterile PBS, pH 7.4

Reconstitution: Please refer to the printed manual for detailed information.

Background: Interleukin-22 receptor subunit alpha-2 (IL-22RA2); also known as interleukin-22-binding protein (IL-22BP); is a subunit of the receptor for interleukin 22. IL-22BP belongs to the type I I cytokine receptor family and contains 3 fibronectin type-III domains. IL-22BP/IL-22RA2 is expressed in a range of tissues; including those in the digestive; female reproductive; and immune systems. It is expressed in placenta; spleen; breast; skin and lung. It is also detected in intestinal tract; testis; brain; heart and thymus. The dominant cell types expressing IL-22BP/IL-22RA2 were mononuclear cells and epithelium. IL-22BP/IL-22RA2 may play an important role as an IL-22 antagonist in the regulation of inflammatory responses. Interleukin-22 (IL-22) is a member of IL-10 family. It is produced by T cells and induces the production of acute-phase reactants. IL-22 plays important roles in immune response through activation of the STAT 3 signal transduction pathway. Two types of IL-22-binding receptor have been discovered; a membrane-bound receptor and a soluble receptor.

Research Area: immunology