Recombinant Human IL-1R8/IL1RAPL1 Protein (Fc Tag) | PKSH033635

Recombinant Human IL-1R8/IL1RAPL1 Protein (Fc Tag) | PKSH033635 | Gentaur US, UK & Europe Disrtribition

Synonyms: Interleukin-1 Receptor Accessory Protein-Like 1; IL-1-RAPL-1; IL-1RAPL-1; IL1RAPL-1; Oligophrenin-4; Three Immunoglobulin Domain-Containing IL-1 Receptor-Related 2; TIGIRR-2; X-Linked Interleukin-1 Receptor Accessory Protein-Like 1; IL1RAPL1; OPHN4

Active Protein: N/A

Activity: Recombinant Human IL-1R8 is produced by our Mammalian expression system and the target gene encoding Leu19-Thr357 is expressed with a Fc tag at the C-terminus.

Protein Construction: Recombinant Human IL-1R8 is produced by our Mammalian expression system and the target gene encoding Leu19-Thr357 is expressed with a Fc tag at the C-terminus.

Fusion Tag: C-Fc

Species: Human

Expressed Host: Human Cells

Shipping: This product is provided as lyophilized powder which is shipped with ice packs.

Purity: > 95 % as determined by reducing SDS-PAGE.

Endotoxin: < 1.0 EU per μg as determined by the LAL method.

Stability and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Molecular Mass: 68 kDa

Formulation: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Reconstitution: Please refer to the printed manual for detailed information.

Background: Interleukin-1 receptor accessory protein-like 1; also known as IL1RAPL1; can be detected at low levels in heart; skeletal muscle; ovary; skin; amygdala; caudate nucleus; corpus callosum; hippocampus; substantia nigra and thalamus. IL1RAPL1 functions as a homodimer; it interacts with NCS1; PTPRD. This interaction is PTPRD-splicing-dependent and induces pre- and post-synaptic differentiation of neurons and is required for IL1RAPL1-mediated synapse formation. During dendritic spine formation; it can bidirectionally induce pre- and post-synaptic differentiation of neurons by trans-synaptically binding to PTPRD.

Research Area: Neuroscience