Recombinant Human IHPK1 Protein (His & GST Tag) | PKSH030322

Recombinant Human IHPK1 Protein (His & GST Tag) | PKSH030322 | Gentaur US, UK & Europe Disrtribition

Synonyms: IHPK1;PiUS

Active Protein: N/A

Activity: A DNA sequence encoding the human IHPK1 (Q92551-1) (Met1-Gln441) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.

Protein Construction: A DNA sequence encoding the human IHPK1 (Q92551-1) (Met1-Gln441) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.

Fusion Tag: N-His & GST

Species: Human

Expressed Host: Baculovirus-Insect Cells

Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at<-20°C.

Purity: > 85 % as determined by reducing SDS-PAGE.

Endotoxin: < 1.0 EU per µg as determined by the LAL method.

Stability and Storage: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Molecular Mass: 78 kDa

Formulation: Supplied as sterile 20mM Tris, 500mM NaCl, pH 8.0, 10% gly

Reconstitution: Not Applicable

Background: IHPK1 is a inositol hexaphosphate kinase (IHPK) protein which belongs to the inositol phosphokinase (IPK) family. IHPK proteins are likely responsible for the conversion of inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). IHPK1 may also convert 1, 3, 4, 5, 6-pentakisphosphate (InsP5) to PP-InsP4 and affect the growth suppressive and apoptotic activities of interferon-beta in some ovarian cancers. During cell death, IHPK1 activity is enhanced, and intracellular InsP7 level is augmented. The distribution of IHPK1 or another predisposing gene affected by position effect of translocation may explain the T2DM phenotype at least in this family.

Research Area: N/A