Description
Recombinant Human HSP27/HSPB1 Protein (His Tag) | PKSH031656 | Gentaur US, UK & Europe Disrtribition
Synonyms: CMT2F;HEL-S-102;HMN2B;HS.76067;Hsp25;HSP27;HSP28;SRP27
Active Protein: N/A
Activity: A DNA sequence encoding the human HSP27 (NP_001531.1) (Met1-Lys205) was expressed with a C-terminal polyhistidine tag.
Protein Construction: A DNA sequence encoding the human HSP27 (NP_001531.1) (Met1-Lys205) was expressed with a C-terminal polyhistidine tag.
Fusion Tag: C-His
Species: Human
Expressed Host: E.coli
Shipping: This product is provided as lyophilized powder which is shipped with ice packs.
Purity: > 97 % as determined by reducing SDS-PAGE.
Endotoxin: Please contact us for more information.
Stability and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Molecular Mass: 28 kDa
Formulation: Lyophilized from sterile 20mM HEPES, 0.1M KCl, pH 7.5
Reconstitution: Please refer to the printed manual for detailed information.
Background: HSP27 is a member of the small heat shock protein family, which also includes HSP25 and the alpha -crystallins. HSP27 forms a large oligomer and the extent of phosphorylation plays a role in determining specific functions. HSP27 also functions as an anti-apoptotic molecule, regulating apoptosis through direct interaction with key components of the apoptotic pathway. HSP27 binds and sequesters cytochrome c released from the mitochondria in response to an apoptotic stimulus. This prevents the proper assembly of the apoptosome and subsequently, the activation of procaspase-9 and procaspase-3.
Research Area: Signal Transduction, Cardiovascular, Cancer,
