Description
Recombinant Human HMGB1 Protein | PKSH033654 | Gentaur US, UK & Europe Disrtribition
Synonyms: High Mobility Group Protein B1; High Mobility Group Protein 1; HMG-1; HMGB1; HMG1
Active Protein: N/A
Activity: Recombinant Human HMGB1 is produced by our E.coli expression system and the target gene encoding Gly2-Phe89 is expressed.
Protein Construction: Recombinant Human HMGB1 is produced by our E.coli expression system and the target gene encoding Gly2-Phe89 is expressed.
Fusion Tag: N/A
Species: Human
Expressed Host: E.coli
Shipping: This product is provided as lyophilized powder which is shipped with ice packs.
Purity: > 95 % as determined by reducing SDS-PAGE.
Endotoxin: < 1.0 EU per μg as determined by the LAL method.
Stability and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Molecular Mass: 10.5 kDa
Formulation: Lyophilized from a 0.2 μm filtered solution of 50mM Hepes, 500mM NaCl, 0.5mM DTT, pH7.9 .
Reconstitution: Please refer to the printed manual for detailed information.
Background: High mobility group protein B1 is a member of the HMGB family consisting of three members; HMGB1; HMGB2 and HMGB3.It Contains 2 HMG box DNA-binding domains entitled box A and box B and It is a highly negative-charged C terminus. As a nuclear protein; HMGB1 stabilizes nucleosomes and allows bending of DNA that facilitates gene transcription which is essential for individual survival. Meanwhile; it is revealed that HMGB1 can also act as a cytokine extracellularlly and regulates monocyte; T cell; dendritic cell activities in inflammatory responses.
Research Area: epigenetics and nuclear signal
