Recombinant Human Histone H4/HIST2H4A Protein | PKSH031359

Recombinant Human Histone H4/HIST2H4A Protein | PKSH031359 | Gentaur US, UK & Europe Disrtribition

Synonyms: FO108;H4;H4/A;H4/B;H4/C;H4/D;H4/E;H4/G;H4/H;H4/J;H4/K;H4/M;H4/N;H4F2;H4FA;H4FB;H4FC;H4FD;H4FE;H4FG;H4FH;H4FI;H4FJ;H4FK;H4FM;H4FN;HIST1H4A;HIST1H4B H4/I;HIST1H4C;HIST1H4D;HIST1H4E;HIST1H4F;HIST1H4H;HIST1H4I;HIST1H4J;HIST1H4K;HIST1H4L;HIST2H4;HIST2H4A

Active Protein: N/A

Activity: A DNA sequence encoding the human Histone H4 (NP_003539.1) (Met1-Gly103) was expressed.

Protein Construction: A DNA sequence encoding the human Histone H4 (NP_003539.1) (Met1-Gly103) was expressed.

Fusion Tag:

Species: Human

Expressed Host: E.coli

Shipping: This product is provided as lyophilized powder which is shipped with ice packs.

Purity: > 95 % as determined by reducing SDS-PAGE.

Endotoxin: Please contact us for more information.

Stability and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Molecular Mass: 11.4 kDa

Formulation: Lyophilized from sterile 2 mM β-ME in dd H2O, pH 6.0

Reconstitution: Please refer to the printed manual for detailed information.

Background: Cyclin E1 is a member of the highly conserved cyclin family and belongs to the E-type cyclin that functions as a regulator of S phase entry and progression in mammalian cells. Cyclin E1 serves as regulatory subunits that bind, activate, and provide substrate for its associated cyclin-dependent kinase2 (CDK2), whose activity is essential for cell cycle G1 / S transition. Over expression of this encoding gene has been found in many tumors, which results in chromosome instability and by extension, induce tumorigenesis. This protein was also found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. In general, cyclin E1, as an activator of phospho-CDK2 (pCDK2), is important for cell cycle progression and is frequently overexpressed in cancer cells.

Research Area: epigenetics and nuclear signal