Recombinant Human GSTP1 Protein | PKSH032496

Recombinant Human GSTP1 Protein | PKSH032496 | Gentaur US, UK & Europe Disrtribition

Synonyms: Glutathione S-transferase P;GSTP1;GST class-pi;GSTP1-1;FAEES3;GST3;

Active Protein: N/A

Activity: Recombinant Human Glutathione S-Transferase pi 1 is produced by our E.coli expression system and the target gene encoding Met1-Glu210 is expressed.

Protein Construction: Recombinant Human Glutathione S-Transferase pi 1 is produced by our E.coli expression system and the target gene encoding Met1-Glu210 is expressed.

Fusion Tag:

Species: Human

Expressed Host: E.coli

Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at<-20°C.

Purity: > 95 % as determined by reducing SDS-PAGE.

Endotoxin: < 1.0 EU per µg as determined by the LAL method.

Stability and Storage: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Molecular Mass: 23.5 kDa

Formulation: Supplied as a 0.2 μm filtered solution of 20mM Tris, 150mM NaCl, 10% Glycerol, pH 8.0.

Reconstitution: Not Applicable

Background: Glutathione S-transferase P (GSTP1) is an enzyme that contains 1 GST C-terminal domain, 1 GST N-terminal domain. GSTP1 belongs to the GST superfamily, the GSTs are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, the soluble GSTs are categorized into 4 main classes: alpha, mu, pi, and theta. The glutathione S-transferase pi gene (GSTP1) is a polymorphic gene encoding active, functionally different GSTP1 variant proteins. Besides, it regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration. It thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases.

Research Area: Cardiovascular, Neuroscience, Cancer, metabolism