Description
Recombinant Human GITRL protein(His tag) | PKSH500063 | Gentaur US, UK & Europe Disrtribition
Synonyms: Activation-inducible TNF-related ligand;AITRL;Glucocorticoid-induced TNF-related ligand;hGITRL
Active Protein: N/A
Activity: A DNA sequence encoding theHuman GITRL protein (Q9UNG2) (Leu49-Ser177) was expressed with a C-His.
Protein Construction: A DNA sequence encoding theHuman GITRL protein (Q9UNG2) (Leu49-Ser177) was expressed with a C-His.
Fusion Tag: C-His
Species: Human
Expressed Host: HEK293 Cells
Shipping: This product is provided as lyophilized powder which is shipped with ice packs.
Purity: > 90 % as determined by reducing SDS-PAGE.
Endotoxin: Please contact us for more information.
Stability and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Molecular Mass: 14.6 kDa
Formulation: Lyophilized from sterile PBS, pH 7.5, 5% trehalose, 5% mannitol, 0.01% tween-80.
Reconstitution: Please refer to the printed manual for detailed information.
Background: Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T-cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1.Promotes leukocyte adhesion to endothelial cells .Regulates migration of monocytes from the splenic reservoir to sites of inflammation.
Research Area: N/A
