Recombinant Human GALK1/Galactokinase Protein (His & GST Tag) | PKSH030368

Recombinant Human GALK1/Galactokinase Protein (His & GST Tag) | PKSH030368 | Gentaur US, UK & Europe Disrtribition

Synonyms: Galactokinase; Galactose Kinase; GALK1; GALK

Active Protein: N/A

Activity: A DNA sequence encoding the human GALK1 (P51570) (Met 1-Leu 392) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.

Protein Construction: A DNA sequence encoding the human GALK1 (P51570) (Met 1-Leu 392) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.

Fusion Tag: N-His & GST

Species: Human

Expressed Host: Baculovirus-Insect Cells

Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at<-20°C.

Purity: > 90 % as determined by reducing SDS-PAGE.

Endotoxin: < 1.0 EU per µg as determined by the LAL method.

Stability and Storage: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Molecular Mass: 70 kDa

Formulation: Supplied as sterile 20mM Tris, 500mM NaCl, 2mM GSH, pH 8.0

Reconstitution: Not Applicable

Background: Galactokinase; also known as Galactose kinase; GALK and GALK1; is a protein which belongs to the GHMP kinase family and GalK subfamily. Galactokinase / GALK1 is a major enzyme for galactose metabolism. Galactokinase (GALK) deficiency is an autosomal recessive disorder characterized by elevation of blood galactose concentration and diminished galactose-1-phosphate; leading to the production of galactitol. Defects in GALK1 are the cause of galactosemia II ( GALCT2 ) which II is an autosomal recessive deficiency characterized by congenital cataracts during infancy and presenile cataracts in the adult population. The cataracts are secondary to accumulation of galactitol in the lenses.

Research Area: Signal Transduction, Cell biology, Cancer, epigenetics and nuclear signal, metabolism,