Recombinant Human GABA Protein (His & FcTag) | PKSH032465

Recombinant Human GABA Protein (His & FcTag) | PKSH032465 | Gentaur US, UK & Europe Disrtribition

Synonyms: GABA(A) Receptor-Associated Protein; GABARAP Protein; HCG1987397 Isoform CRA_b; GABARAP

Active Protein: N/A

Activity: Recombinant Human GABA(A) receptor-Associated Protein is produced by our E.coli expression system and the target gene encoding Met1-Gln116 is expressed with a 6His tag at the N-terminus; Fc tag at the C-terminus.

Protein Construction: Recombinant Human GABA(A) receptor-Associated Protein is produced by our E.coli expression system and the target gene encoding Met1-Gln116 is expressed with a 6His tag at the N-terminus; Fc tag at the C-terminus.

Fusion Tag: N-6His;C-Fc

Species: Human

Expressed Host: E.coli

Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at<-20°C.

Purity: > 90 % as determined by reducing SDS-PAGE.

Endotoxin: < 1.0 EU per µg as determined by the LAL method.

Stability and Storage: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Molecular Mass: 43.2 kDa

Formulation: Supplied as a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, 20% glycerol, pH7.0.

Reconstitution: Not Applicable

Background: Gamma-Aminobutyric Acid Receptor-Associated Protein (GABARAP) is a ligand-gated chloride channel protein that mediates inhibitory neurotransmission and belongs to the MAP1 LC3 family. GABARAP is highly positively charged in its N-terminus and shares sequence similarity with light chain-3 of microtubule-associated proteins 1A and 1B. GABARAP clusters neurotransmitter receptors by mediating interaction with the cytoskeleton. Autophagy is the process by which cells recycle cytoplasm and dispose of excess or defective organelles. This process is suggested to be involved development; differentiation; growth regulation and tissue remodeling in multicellular organisms. An important inhibitory neurotransmitter; GABA; acts on GABA receptors that are ubiquitously expressed in the CNS. GABARAP has been shown to play a important role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton.

Research Area: N/A