Recombinant Human G-CSFR/CD114 Protein (Active) | PKSH031747

Recombinant Human G-CSFR/CD114 Protein (Active) | PKSH031747 | Gentaur US, UK & Europe Disrtribition

Synonyms: CD114;CSF3R;G-CSF R;GCSFR

Active Protein: Active protein

Activity: The mature form of human G-CSF receptor (NP_000751.1) extracellular domain (Met 1-Pro 621) with five aminio acids at the C-terminus was expressed and purified.

Protein Construction: The mature form of human G-CSF receptor (NP_000751.1) extracellular domain (Met 1-Pro 621) with five aminio acids at the C-terminus was expressed and purified.

Fusion Tag:

Species: Human

Expressed Host: HEK293 Cells

Shipping: This product is provided as lyophilized powder which is shipped with ice packs.

Purity: > 85 % as determined by reducing SDS-PAGE.

Endotoxin: < 1.0 EU per µg as determined by the LAL method.

Stability and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Molecular Mass: 69.0 kDa

Formulation: Lyophilized from sterile PBS, pH 7.4

Reconstitution: Please refer to the printed manual for detailed information.

Background: Granulocyte Colony Stimulating Factor Receptor (G-CSFR), also known as CD114, which belongs to the cytokine receptor superfamily, is a cell surface receptor for colony stimulating factor 3 (CSF3). It is a critical regulator of granulopoiesis. This type I membrane protein has a composite structure consisting of an immunoglobulin(Ig)-like domain, a cytokine receptor-homologous (CRH) domain and three fibronectin type III (FNIII) domains in the extracellular region. Mutations in the G-CSF receptor leading to carboxy-terminal truncation transduce hyperproliferative growth responses, and are implicated in the pathological progression of severe congenital neutropenia (SCN) to acute myelogenous leukemia (AML). Additionally, autocrine/paracrine stimulation of G-CSFR may be important in the biology of solid tumors, including metastasis.

Research Area: Cancer, immunology, Stem cells