Description
Recombinant Human Fumarase/FH Protein | PKSH032462 | Gentaur US, UK & Europe Disrtribition
Synonyms: Fumarate Hydratase Mitochondrial; Fumarase; FH;FMRD;HLRCC;LRCC;MCL;MCUL1
Active Protein: N/A
Activity: Recombinant Human Fumarase is produced by our E.coli expression system and the target gene encoding Ala45-Lys510 is expressed.
Protein Construction: Recombinant Human Fumarase is produced by our E.coli expression system and the target gene encoding Ala45-Lys510 is expressed.
Fusion Tag:
Species: Human
Expressed Host: E.coli
Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at<-20°C.
Purity: > 95 % as determined by reducing SDS-PAGE.
Endotoxin: < 1.0 EU per µg as determined by the LAL method.
Stability and Storage: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Molecular Mass: 50.2 kDa
Formulation: Supplied as a 0.2 μm filtered solution of 20mM Tris, pH 8.0.
Reconstitution: Not Applicable
Background: Fumarase is an enzyme that catalyze the reversible hydration/dehydration of fumarate to S-malate and is involved in the tricarboxylic acid or Krebs cycle. Fumarase exists in both form, cytosolic formand N-terminal extend mitochondrial form. The N-terminal extended form is targeted to the mitochondrion, where the removal of the extension is the same form as in the cytoplasm. Fumarase is thought to act as a tumor suppressor, which deficiency can lead to progressive encephalopathy, cerebral atrophy and development delay.
Research Area: Signal Transduction, Cancer, metabolism,
