Recombinant Human Frizzled-4/FZD4 Protein (Fc Tag) | PKSH030493

Recombinant Human Frizzled-4/FZD4 Protein (Fc Tag) | PKSH030493 | Gentaur US, UK & Europe Disrtribition

Synonyms: CD344;EVR1;FEVR;Fz-4;Fz4;FZD4S;FzE4;GPCR;hFz4

Active Protein: N/A

Activity: A DNA sequence encoding the human FZD4 (NP_036325.2) (Met1-Glu180) was expressed with the Fc region of human IgG1 at the C-terminus.

Protein Construction: A DNA sequence encoding the human FZD4 (NP_036325.2) (Met1-Glu180) was expressed with the Fc region of human IgG1 at the C-terminus.

Fusion Tag: C-Fc

Species: Human

Expressed Host: HEK293 Cells

Shipping: This product is provided as lyophilized powder which is shipped with ice packs.

Purity: > 95 % as determined by reducing SDS-PAGE.

Endotoxin: < 1.0 EU per µg of the protein as determined by the LAL method.

Stability and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Molecular Mass: 43.3 kDa

Formulation: Lyophilized from sterile PBS, pH 7.4

Reconstitution: Please refer to the printed manual for detailed information.

Background: This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This protein may play a role as a positive regulator of the Wingless type MMTV integration site signaling pathway. A transcript variant retaining intronic sequence and encoding a shorter isoform has been described; however; its expression is not supported by other experimental evidence.

Research Area: Signal Transduction, Cancer, epigenetics and nuclear signal, Stem cells