Recombinant Human FLRT2 Protein (His Tag)(Active) | PKSH031164

Recombinant Human FLRT2 Protein (His Tag)(Active) | PKSH031164 | Gentaur US, UK & Europe Disrtribition

Synonyms: Leucine-Rich Repeat Transmembrane Protein FLRT2; Fibronectin-Like Domain-Containing Leucine-Rich Transmembrane Protein 2; FLRT2; KIAA0405

Active Protein: Active protein

Activity: A DNA sequence encoding the human FLRT2 (O43155) extracellular domain (Met 1-Ser 539) was expressed; with a C-terminal polyhistidine tag.

Protein Construction: A DNA sequence encoding the human FLRT2 (O43155) extracellular domain (Met 1-Ser 539) was expressed; with a C-terminal polyhistidine tag.

Fusion Tag: C-His

Species: Human

Expressed Host: HEK293 Cells

Shipping: This product is provided as lyophilized powder which is shipped with ice packs.

Purity: > 98 % as determined by reducing SDS-PAGE.

Endotoxin: < 1.0 EU per µg of the protein as determined by the LAL method.

Stability and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Molecular Mass: 57.7 kDa

Formulation: Lyophilized from sterile PBS, pH 7.4

Reconstitution: Please refer to the printed manual for detailed information.

Background: Fibronectin Leucine-Rich Transmembrane (FLRT) proteins are glycosylated membrane proteins expressed at the cell surface which localise in a homophilic manner to cell-cell contacts expressing the focal adhesion marker vinculin. FLRT1; FLRT2; and FLRT3; the three genes encode putative type I transmembrane proteins; each containing 10 leucine-rich repeats (LRR); a type III fibronectin (FN) domain; followed by the transmembrane region; and a short cytoplasmic tail. FLRT family members may function in cell adhesion and/or receptor signalling. Each member of the FLRT family has a distinct; highly regulated expression pattern; as was seen for the NLRR family. FLRT2 is expressed in a subset of the sclerotome; adjacent to the region that forms the syndetome; suggesting that interaction with FGF signalling may be a general property of FLRT proteins. All FLRTs can interact with FGFR1 and FLRTs can be induced by the activation of FGF signalling by FGF-2. FLRT proteins have a dual role; promoting FGF signalling and modulating homotypic cell adhesion. FLRT2 played critical roles in craniofacial development; and it was also present in the vomero-nasal organ; mandibular primodia; and the posterior aspects of the unfused and fused secondary palatal shelves.

Research Area: Signal Transduction, Stem cells