Recombinant Human FKBP3/FKBP25 Protein (His Tag) | PKSH032876

Recombinant Human FKBP3/FKBP25 Protein (His Tag) | PKSH032876 | Gentaur US, UK & Europe Disrtribition

Synonyms: Peptidyl-prolyl cis-trans isomerase FKBP3;PPIase FKBP3;25 kDa FK506-binding protein;25 kDa FKBP;FKBP-25;FK506-binding protein 3;FKBP-3;Immunophilin FKBP25;Rapamycin-selective 25 kDa immunophilin;Rotamase;FKBP25

Active Protein: N/A

Activity: Recombinant Human 25 kDa FK506-binding protein is produced by our E.coli expression system and the target gene encoding Met1-Asp224 is expressed with a 6His tag at the N-terminus.

Protein Construction: Recombinant Human 25 kDa FK506-binding protein is produced by our E.coli expression system and the target gene encoding Met1-Asp224 is expressed with a 6His tag at the N-terminus.

Fusion Tag: N-6His

Species: Human

Expressed Host: E.coli

Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at<-20°C.

Purity: > 95 % as determined by reducing SDS-PAGE.

Endotoxin: < 1.0 EU per µg as determined by the LAL method.

Stability and Storage: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Molecular Mass: 27.3 kDa

Formulation: Supplied as a 0.2 μm filtered solution of 20mM TrisHCl, 1mM DTT, 10% glycerol .

Reconstitution: Not Applicable

Background: FKBP25 contains 1 PPIase FKBP-type domain; belongs to the FKBP-type PPIase family. FK506- and rapamycin-binding proteins (FKBPs) constitute a family of receptors for the two immunosuppressants which inhibit T-cell proliferation by arresting two distinct cytoplasmic signal transmission pathways. FKBP3 is a cis-trans prolyl isomerase enzyme that binds the immunosuppressants FK506 and rapamycin; as well as histone deacetylases; the transcription factor YY1; casein kinase II; and nucleolin. It has a higher affinity for rapamycin than for FK506 and thus may be an important target molecule for immunosuppression by rapamycin.

Research Area: epigenetics and nuclear signal