Description
Recombinant Human Fibronectin/FN Protein (His & Avi Tag) | PKSH033677 | Gentaur US, UK & Europe Disrtribition
Synonyms: Fibronectin; FN1; CIG; ED-B; FINC; FN; FNZ; GFND; GFND2; LETS; MSF
Active Protein: N/A
Activity: Recombinant Human Fibronectin is produced by our E.coli expression system and the target gene encoding Glu5-Thr95 is expressed with a 6His; Avi tag at the N-terminus.
Protein Construction: Recombinant Human Fibronectin is produced by our E.coli expression system and the target gene encoding Glu5-Thr95 is expressed with a 6His; Avi tag at the N-terminus.
Fusion Tag: N-His-Avi
Species: Human
Expressed Host: E.coli
Shipping: This product is provided as lyophilized powder which is shipped with ice packs.
Purity: > 95 % as determined by reducing SDS-PAGE.
Endotoxin: < 1.0 EU per μg as determined by the LAL method.
Stability and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Molecular Mass: 13.4 kDa
Formulation: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
Reconstitution: Please refer to the printed manual for detailed information.
Background: Fibronectin is a high-molecular weight glycoprotein of the extracellular matrix that binds to membrane-spanning receptor proteins called integrins. Similar to integrins; fibronectin binds extracellular matrix components such as collagen; fibrin; and heparan sulfate proteoglycans. Fibronectin plays a major role in cell adhesion; growth; migration; and differentiation; and it is important for processes such as wound healing and embryonic development. Altered fibronectin expression; degradation; and organization has been associated with a number of pathologies; including cancer and fibrosis. Anastellin binds fibronectin and induces fibril formation. This fibronectin polymer; named superfibronectin; exhibits enhanced adhesive properties. Both anastellin and superfibronectin inhibit tumor growth; angiogenesis and metastasis. Anastellin activates p38 MAPK and inhibits lysophospholipid signaling.
Research Area: Signal Transduction, Cardiovascular, Cancer, Developmental Biology, Stem cells
