Description
Recombinant Human FBPase 1/FBP1 Protein (Human Cells, His Tag) | PKSH033277 | Gentaur US, UK & Europe Disrtribition
Synonyms: Fructose-1;6-bisphosphatase 1;D-fructose-1;6-bisphosphate 1-phosphohydrolase 1;FBP;FBPase 1
Active Protein: N/A
Activity: Recombinant Human Fructose-1;6-Bisphosphatase 1 is produced by our Mammalian expression system and the target gene encoding Ala2-Gln338 is expressed with a 6His tag at the C-terminus.
Protein Construction: Recombinant Human Fructose-1;6-Bisphosphatase 1 is produced by our Mammalian expression system and the target gene encoding Ala2-Gln338 is expressed with a 6His tag at the C-terminus.
Fusion Tag: C-6His
Species: Human
Expressed Host: Human Cells
Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at<-20°C.
Purity: > 95 % as determined by reducing SDS-PAGE.
Endotoxin: < 1.0 EU per µg as determined by the LAL method.
Stability and Storage: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Molecular Mass: 37.8 kDa
Formulation: Supplied as a 0.2 μm filtered solution of 20mM TrisHCl, 200mM NaCl, 1mM DTT, 10% Glycerol, pH 8.0.
Reconstitution: Not Applicable
Background: Fructose-1;6-bisphosphatase 1(FBP1) is a homotetramer protein and belongs to the FBPase class 1 family. It involves in carbohydrate biosynthesis; gluconeogenesis pathway. FBP1 is a gluconeogenesis regulatory protein which catalyzes the hydrolysis of fructose 1;6-bisphosphate to fructose 6-phosphate and inorganic phosphate. FBP1 deficiency is associated with hypoglycemia and metabolic acidosis. FBP1 regulates mouse endogenous glucose production. FBP1 coupled with phosphofructokinase (PFK) takes part in the metabolism of pancreatic islet cells.
Research Area: Signal Transduction, Cancer, epigenetics and nuclear signal, metabolism,
