Recombinant Human FBPase 1/FBP1 Protein (E. coli, His Tag) | PKSH033276

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SKU:
575-PKSH033276
€656.00
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Description

Recombinant Human FBPase 1/FBP1 Protein (E. coli, His Tag) | PKSH033276 | Gentaur US, UK & Europe Disrtribition

Synonyms: Fructose-1;6-Bisphosphatase 1; FBPase 1; D-Fructose-1;6-Bisphosphate 1-Phosphohydrolase 1; FBP1; FBP

Active Protein: N/A

Activity: Recombinant Human Fructose-1;6-Bisphosphatase 1 is produced by our E.coli expression system and the target gene encoding Ala2-Gln338 is expressed with a 6His tag at the C-terminus.

Protein Construction: Recombinant Human Fructose-1;6-Bisphosphatase 1 is produced by our E.coli expression system and the target gene encoding Ala2-Gln338 is expressed with a 6His tag at the C-terminus.

Fusion Tag: C-6His

Species: Human

Expressed Host: E.coli

Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at<-20°C.

Purity: > 85 % as determined by reducing SDS-PAGE.

Endotoxin: < 1.0 EU per µg as determined by the LAL method.

Stability and Storage: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Molecular Mass: 37.9 kDa

Formulation: Supplied as a 0.2 μm filtered solution of 20mM TrisHCl, 200mM NaCl, 1mM DTT, 1mM EDTA, 20% Glycerol, pH 8.0.

Reconstitution: Not Applicable

Background: Fructose-1;6-Bisphosphatase 1 (FBPase 1) is a member of the FBPase class 1 family. FBPase 1 is a gluconeogenesis regulatory protein; which catalyzes the hydrolysis of fructose 1;6-bisphosphate to fructose 6-phosphate and inorganic phosphate. FBPase 1 can assume an active R-state; or an inactive T-state. FBPase 1 deficiency is inherited as an autosomal recessive disorder mainly in the liver and causes life-threatening episodes of hypoglycemia and metabolic acidosis in newborn infants or young children. FBPase 1 coupled with phosphofructokinase (PFK) is involved in the metabolism of pancreatic islet cells.

Research Area: Signal Transduction, Cancer, epigenetics and nuclear signal, metabolism,

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