Recombinant Human FABP4/A-FABP Protein (29 Ala/Thr, His Tag) | PKSH030902

Recombinant Human FABP4/A-FABP Protein (29 Ala/Thr, His Tag) | PKSH030902 | Gentaur US, UK & Europe Disrtribition

Synonyms: Fatty Acid-Binding Protein Adipocyte; Adipocyte Lipid-Binding Protein; ALBP; Adipocyte-Type Fatty Acid-Binding Protein; A-FABP; AFABP; Fatty Acid-Binding Protein 4; aP2;HEL-S-104

Active Protein: N/A

Activity: A DNA sequence encoding the human FABP4 (P15090) (Cys 2-Ala 132) (29 Ala / Thr) was expressed; with a polyhistide tag at the N-terminus.

Protein Construction: A DNA sequence encoding the human FABP4 (P15090) (Cys 2-Ala 132) (29 Ala / Thr) was expressed; with a polyhistide tag at the N-terminus.

Fusion Tag: N-His

Species: Human

Expressed Host: E.coli

Shipping: This product is provided as lyophilized powder which is shipped with ice packs.

Purity: > 95 % as determined by reducing SDS-PAGE.

Endotoxin: Please contact us for more information.

Stability and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Molecular Mass: 16 kDa

Formulation: Lyophilized from sterile 50mM Tris, 200mM NaCl, 10% glycerol, pH 8.2

Reconstitution: Please refer to the printed manual for detailed information.

Background: Fatty acid-binding protein; adipocyte; also known as Adipocyte-type fatty acid-binding protein; Fatty acid-binding protein 4; Adipocyte lipid-binding protein; and FABP4; is a cytoplasm protein which belongs to the calycin superfamily and Fatty-acid binding protein (FABP) family. In familial combined hyperlipidemia (FCHL); FABP4 correlated to body mass index (BMI); waist circumference and homeostasis model assessment (HOMA) index.FABP4 levels were associated with triglyceride-rich lipoproteins. In humans serum FABP4 levels correlate significantly with features of PCOS. It appears to be a determinant of atherogenic dyslipidemia. FABP4 pathway mediates the sebaceous gland hyperplasia in keratinocyte-specific Pten-null mice. FABP4 concentration significantly increased with an increasing of MS features and was strongly correlated with body-mass index; triglycerides; HDL-cholesterol concentrations and blood pressure. Patients in the highest quartile of FABP4 presented a six-fold increased odds ratio for MS and a three-fold increased odds for LD; adjusted by age; sex; body-mass index and the antiretroviral therapy. FABP4 is a strong plasma marker of metabolic disturbances in HIV-infected patients; and therefore; could serve to guide therapeutic intervention in this group of patients.

Research Area: Signal Transduction, Cardiovascular, Cancer, metabolism, Stem cells