Recombinant Human Eotaxin-3/CCL26 Protein (aa 24-94) | PKSH033733

Recombinant Human Eotaxin-3/CCL26 Protein (aa 24-94) | PKSH033733 | Gentaur US, UK & Europe Disrtribition

Synonyms: C-C Motif Chemokine 26; CC Chemokine IMAC; Eotaxin-3; Macrophage Inflammatory Protein 4-Alpha; MIP-4-Alpha; Small-Inducible Cytokine A26; Thymic Stroma Chemokine-1; TSC-1; CCL26; SCYA26

Active Protein: N/A

Activity: Recombinant Human CCL26 is produced by our E.coli expression system and the target gene encoding Thr24-Leu94 is expressed.

Protein Construction: Recombinant Human CCL26 is produced by our E.coli expression system and the target gene encoding Thr24-Leu94 is expressed.

Fusion Tag: N/A

Species: Human

Expressed Host: E.coli

Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at<-20°C.

Purity: > 95 % as determined by reducing SDS-PAGE.

Endotoxin: < 1.0 EU per μg as determined by the LAL method.

Stability and Storage: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Molecular Mass: 8.53 kDa

Formulation: Supplied as a 0.2 μm filtered solution of 20mM Tris, 1mM EDTA, 20% Glycerol, pH 9.0.

Reconstitution: Not Applicable

Background: Chemokine Ligand 26 protein (CCL26) is a novel small cytokine belonging to the CC chemokine family which is involved in immunoregulatory and inflammatory processes. CCL26 is constitutively expressed in thymus; but only transiently expressed in phytohemagglutinin-stimulated peripheral blood mononuclear cells. It specifically binds and induces chemotaxis in T cells and elicits its effects by interacting with the chemokine receptor CCR4. CCL26; along with Eotaxin-1 and Eotaxin-2; selectively activates the CC chemokine receptor 3 (CCR3). The Eotaxin-3-CCR3 interaction may play an important role in allergic diseases such as atopic dermatitis and bronchial asthma. The full-length cDNA for CCL26 encodes a protein of 94 amino acids with a putative signal peptide of either 23 or 26 amino acid residues. Both the 71 and 68 amino acid residue variants of recombinant CCL26 demonstrate equal potency in inducing chemotaxis of a human CCR3-transfected cell line. Unlike most other CC chemokines; CCL26 maps to human chromosome 7q11.2; within 40 kilobases of the Eotaxin-2 loci. CCL26 and Eotaxin-2 are unique in that they are the only chemokines identified to date that map to chromosome 7.

Research Area: immunology