Description
Recombinant Human EBP1/PA2G4 Protein (His Tag) | PKSH030761 | Gentaur US, UK & Europe Disrtribition
Synonyms: EBP1;HG4-1;p38-2G4
Active Protein: N/A
Activity: A DNA sequence encoding the human PA2G4 (Q9UQ80) (Ser 2-Asp 394) was expressed, with a polyhistide tag at the N-terminus.
Protein Construction: A DNA sequence encoding the human PA2G4 (Q9UQ80) (Ser 2-Asp 394) was expressed, with a polyhistide tag at the N-terminus.
Fusion Tag: N-His
Species: Human
Expressed Host: E.coli
Shipping: This product is provided as lyophilized powder which is shipped with ice packs.
Purity: > 92 % as determined by reducing SDS-PAGE.
Endotoxin: Please contact us for more information.
Stability and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Molecular Mass: 45.2 kDa
Formulation: Lyophilized from sterile 20mM Tris, 0.5M NaCl, pH 8.0
Reconstitution: Please refer to the printed manual for detailed information.
Background: EBP1, also known as PA2G4, is an RNA-binding protein which belongs to the peptidase M24 family. It can be detected n several cell lines tested, including primary and transformed cell lines. EBP1 also present in pre-ribosomal ribonucleoprotein complexes and may be involved in ribosome assembly and the regulation of intermediate and late steps of rRNA processing. This protein is a transcriptional co-repressor of androgen receptor-regulated genes and other cell cycle regulatory genes through its interactions with histone deacetylases. PA2G4 can interact with the cytoplasmic domain of the ErbB3 receptor and may contribute to transducing growth regulatory signals. EBP1 has been implicated in growth inhibition and the induction of differentiation of human cancer cells. It seems to be involved in growth regulation. EBP1 also mediates cap-independent translation of specific viral IRESs (internal ribosomal entry site).
Research Area: epigenetics and nuclear signal
