Recombinant Human DIM1/TXNL4A Protein (His Tag) | PKSH030841

Recombinant Human DIM1/TXNL4A Protein (His Tag) | PKSH030841 | Gentaur US, UK & Europe Disrtribition

Synonyms: BMKS;DIB1;DIM1;SNRNP15;TXNL4;U5-15kD

Active Protein: N/A

Activity: A DNA sequence encoding the human TXNL4A (P83876) (Met 1-Tyr 142) was expressed, with a polyhistidine tag at the N-terminus.

Protein Construction: A DNA sequence encoding the human TXNL4A (P83876) (Met 1-Tyr 142) was expressed, with a polyhistidine tag at the N-terminus.

Fusion Tag: N-His

Species: Human

Expressed Host: E.coli

Shipping: This product is provided as lyophilized powder which is shipped with ice packs.

Purity: > 94 % as determined by reducing SDS-PAGE.

Endotoxin: Please contact us for more information.

Stability and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Molecular Mass: 18.6kDa

Formulation: Lyophilized from sterile 50mM Tris, 150mM NaCl, pH 8.0

Reconstitution: Please refer to the printed manual for detailed information.

Background: DIM1, also known as TXNL4A, is a member of the Dim protein family. The Dim protein family is composed of two classes, DIM1and Dim2, which share a common thioredoxin-like fold. They were originally identified for their role in cell cycle progression and have been found to interact with Prp6, an essential component of the spliceosome, which forms the bridge of U4/U6.U5-tri-snRNP. In spite of their biological and structural similarities, DIM1 and Dim2 proteins differ in many aspects. DIM1 bears distinctive structural motifs responsible for its interaction with other spliceosome components. Dim2 forms homodimers and contains specific domains required for its interactions with partners. This originality suggests that although both proteins are involved in pre-mRNA splicing, they are likely to be involved in different biological pathways. DIM1 interacts with HNRPF, HNRPH2, NEDD9/HEF1 and PQBP1/NPW38. It plays an essential role in pre-mRNA splicing.

Research Area: epigenetics and nuclear signal