Description
Recombinant Human Dectin-1/CLEC7A Protein (Fc Tag) | PKSH033706 | Gentaur US, UK & Europe Disrtribition
Synonyms: Beta-glucan receptor; BGR; CD369; CLEC7A; CLECSF12; CLECSF12DC-associated C-type lectin 1;Dectin1; Dectin-1; DECTIN1CANDF4;CANDF4;DECTIN1
Active Protein: N/A
Activity: Recombinant Human Dectin-1 is produced by our Mammalian expression system and the target gene encoding Thr66-Met247 is expressed with a Fc tag at the N-terminus.
Protein Construction: Recombinant Human Dectin-1 is produced by our Mammalian expression system and the target gene encoding Thr66-Met247 is expressed with a Fc tag at the N-terminus.
Fusion Tag: N-Fc
Species: Human
Expressed Host: Human Cells
Shipping: This product is provided as lyophilized powder which is shipped with ice packs.
Purity: > 85 % as determined by reducing SDS-PAGE.
Endotoxin: < 1.0 EU per μg as determined by the LAL method.
Stability and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Molecular Mass: 46.9 kDa
Formulation: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Reconstitution: Please refer to the printed manual for detailed information.
Background: Dectin-1 was recently identified as the most important receptor for beta-glucan. It is a type II transmembrane protein which binds beta-1, 3 and beta-1, 6 glucans, and is expressed on most cells of the innate immune system and has been implicated in phagocytosis as well as killing of fungi by macrophages, neutrophils and dendritic cells. Recognition of beta-glucan by dectin-1 triggers effective immune response, including phagocytosis and proinflammatory factor production, to eliminate infecting fungi, which especially benefits immunocompromised patients against opportunistic fungal infection.
Research Area: immunology
