Recombinant Human Cyclophilin A Protein | PKSH033420

Recombinant Human Cyclophilin A Protein | PKSH033420 | Gentaur US, UK & Europe Disrtribition

Synonyms: Peptidyl-prolyl cis-trans isomerase A; PPIase A; Cyclophilin A; Cyclosporin A-binding protein; Rotamase A; SP18; PPIA; CYPA

Active Protein: N/A

Activity: Recombinant Human Peptidyl-prolyl Cis-trans Isomerase A is produced by our E.coli expression system and the target gene encoding Met1-Glu165 is expressed.

Protein Construction: Recombinant Human Peptidyl-prolyl Cis-trans Isomerase A is produced by our E.coli expression system and the target gene encoding Met1-Glu165 is expressed.

Fusion Tag:

Species: Human

Expressed Host: E.coli

Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at<-20°C.

Purity: > 95 % as determined by reducing SDS-PAGE.

Endotoxin: < 1.0 EU per µg as determined by the LAL method.

Stability and Storage: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Molecular Mass: 18 kDa

Formulation: Supplied as a 0.2 μm filtered solution of PBS, 10%glycerol, pH7.4 .

Reconstitution: Not Applicable

Background: Peptidyl-prolyl cis-trans isomerase A is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family; which catalyzes the cis-trans isomerization of proline imidic peptide bonds. Cyclophilin A regulate many biological processes; including intracellular signaling; transcription; inflammation; and apoptosis. Cyclophilin is also incorporated into many viruses; including HIV1; where it has been speculated to be involved in functions such as viral assembly and infectivity. The immunosuppressive activity of cyclosporins has been correlated with their ability to form complexes with cyclophilins that inhibit calcineurin phosphatase activity and prevent incorporation of cyclophilin into viral particles. The cyclosporin/cyclophilin complex selectively binds and inactivates calcineurin; making it a useful inhibitor for studying calcineurin activity.

Research Area: Signal Transduction, immunology,