Description
Recombinant Human CXCR4 (C28A) Protein (His Tag) | PKSH500022 | Gentaur US, UK & Europe Disrtribition
Synonyms: C-X-C chemokine receptor type 4, CD184, FB22, Fusin, HM89, HSY3RR, LAP3, LCR1, NPYR, SDF 1 receptor, WHIM
Active Protein: N/A
Activity: A DNA sequence encoding the human CXCR4 (C28A) (1M-38K) was expressed with a GST tag at the N-terminus.
Protein Construction: A DNA sequence encoding the human CXCR4 (C28A) (1M-38K) was expressed with a GST tag at the N-terminus.
Fusion Tag: N-GST
Species: Human
Expressed Host: E.coli
Shipping: This product is provided as lyophilized powder which is shipped with ice packs.
Purity: > 95 % as determined by reducing SDS-PAGE.
Endotoxin: Please contact us for more information.
Stability and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Molecular Mass: 31.2kDa
Formulation: Lyophilized from sterile potassium phosphate, pH 7.4
Reconstitution: Please refer to the printed manual for detailed information.
Background: Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ions levels and enhancing MAPK1/MAPK3 activation. Acts as a receptor for extracellular ubiquitin; leading to enhance intracellular calcium ions and reduce cellular cAMP levels. Involved in haematopoiesis and in cardiac ventricular septum formation. Plays also an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Could be involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 X4 isolates and as a primary receptor for some HIV-2 isolates. Promotes Env-mediated fusion of the virus.
Research Area: Microbiology, Neuroscience, Cancer, immunology, metabolism, Stem cells
