Recombinant Human CUTC/CGI-32 Protein (His Tag) | PKSH031114

Recombinant Human CUTC/CGI-32 Protein (His Tag) | PKSH031114 | Gentaur US, UK & Europe Disrtribition

Synonyms: CGI-32

Active Protein: N/A

Activity: A DNA sequence encoding the human CUTC (Q9NTM9) (Met 1-Val 273) was expressed, with an N-terminal polyhistidine tag.

Protein Construction: A DNA sequence encoding the human CUTC (Q9NTM9) (Met 1-Val 273) was expressed, with an N-terminal polyhistidine tag.

Fusion Tag: N-His

Species: Human

Expressed Host: E.coli

Shipping: This product is provided as lyophilized powder which is shipped with ice packs.

Purity: > 92 % as determined by reducing SDS-PAGE.

Endotoxin: Please contact us for more information.

Stability and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Molecular Mass: 31 kDa

Formulation: Lyophilized from sterile PBS, 10% glycerol, pH 7.4

Reconstitution: Please refer to the printed manual for detailed information.

Background: Copper homeostasis protein cutC homolog, also known as CGI-32 and CUTC, is a cytoplasm and nucleus protein which belongs to the CutC family. CUTC may play a role in copper homeostasis. It can bind one Cu1+ per subunit. Copper is an essential trace element to life and particularly plays a pivotal role in the physiology of aerobic organisms. Copper is a micronutrient that is required for proper metabolic functioning of most prokaryotic and eukaryotic organisms. To sustain an adequate supply of copper, a cell requires molecular mechanisms that control the metal content to avoid copper toxicity. This toxicity comes primarily from the reactivity of copper, which can lead to the generation of free radicals. In bacteria, two independent systems are responsible for maintaining the balance of copper within the cells ( Cop and Cut family proteins ). The Cut protein family is associated with copper homeostasis and involved in uptake, storage, delivery, and efflux of copper. CutC is a member of the Cut family and is suggested to be involved in efflux trafficking of cuprous ion. CutC is able to respond transcriptionally to copper and to participate in the control of copper homeostasis in E. faecalis.

Research Area: Signal Transduction, metabolism,