Recombinant Human CSNK1G2 Protein (His Tag) | PKSH032010

Recombinant Human CSNK1G2 Protein (His Tag) | PKSH032010 | Gentaur US, UK & Europe Disrtribition

Synonyms: Casein kinase I isoform gamma-2; CK1G2; CSNK1G2

Active Protein: N/A

Activity: Recombinant Human Casein kinase I isoform gamma-2 is produced by our E.coli expression system and the target gene encoding Met18-Lys415 is expressed with a 6His tag at the N-terminus.

Protein Construction: Recombinant Human Casein kinase I isoform gamma-2 is produced by our E.coli expression system and the target gene encoding Met18-Lys415 is expressed with a 6His tag at the N-terminus.

Fusion Tag: N-6His

Species: Human

Expressed Host: E.coli

Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at<-20°C.

Purity: > 90 % as determined by reducing SDS-PAGE.

Endotoxin: < 1.0 EU per µg as determined by the LAL method.

Stability and Storage: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Molecular Mass: 47.6 kDa

Formulation: Supplied as a 0.2 μm filtered solution of 20mM Tris, 500mM NaCl, 10%Glycerol, 1mM DTT, pH 8.0.

Reconstitution: Not Applicable

Background: Casein kinase I gamma 2 isoform (CSNK1G2); a member of the large casein kinase I (CKI) subfamily; protein kinase superfamily. It may affect the development of brain; and associate with vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. The CKI family includes several other isoforms (alpha; beta; gamma; and delta). Dishevelled (Dsh); another positive component of the Wnt pathway; becomes phosphorylated in response to Wnt signals. All the CKI isoforms; with the exception of gamma; increase the phosphorylation of Dsh in vivo. Casein kinase 1 gamma (CK1gamma; or CSNK1G) is associated with the cell membrane and binds to LRP. CK1gamma was found to be needed for Wnt signaling through Wnt receptor LRP. CSNK1G2 inhibits Smad3-mediated TGF-beta responses including induction of target genes and cell growth arrest; and this inhibition is dependent on CSNK1G2 kinase activity. The overexpression of CSNK1G2 in human cancers; may act as an oncoprotein during tumorigenesis. In addition; as an MTA1s-binding protein; CSNK1G2 could further potentiate the estrogen receptor (ER) corepressive function of MTA1s.

Research Area: N/A