Recombinant Human CMPK1 Protein (His Tag) | PKSH030319

Recombinant Human CMPK1 Protein (His Tag) | PKSH030319 | Gentaur US, UK & Europe Disrtribition

Synonyms: CK;CMK;CMPK;UMK;UMP-CMPK;UMPK

Active Protein: N/A

Activity: A DNA sequence encoding the human CMPK1 (P30085) (Met1-Gly196) was fused with a polyhistide tag at the N-terminus.

Protein Construction: A DNA sequence encoding the human CMPK1 (P30085) (Met1-Gly196) was fused with a polyhistide tag at the N-terminus.

Fusion Tag: N-His

Species: Human

Expressed Host: Baculovirus-Insect Cells

Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at<-20°C.

Purity: > 95 % as determined by reducing SDS-PAGE.

Endotoxin: < 1.0 EU per µg as determined by the LAL method.

Stability and Storage: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Molecular Mass: 24.5 kDa

Formulation: Supplied as sterile 20mM Tris, 500mM Nacl, pH 7.4, 10% glycerol

Reconstitution: Not Applicable

Background: CMPK1 plays a key role in the maintenance of pyrimidine nucleotide pool profile and for the metabolism of pyrimidine analogs in cells. It catalyzes the phosphoryl transfer from ATP to UMP, CMP, and deoxy-CMP (dCMP), resulting in the formation of ADP and the corresponding nucleoside diphosphate. CMPK1 also has a significant role in the activation of pyrimidine analogs, which are clinically useful anti-cancer and anti-viral drugs. In the meanwhile, CMPK1 functions in cellular nucleic acid biosynthesis.

Research Area: epigenetics and nuclear signal, metabolism