Recombinant Human Chitotriosidase/CHIT1 Protein (His Tag) | PKSH032245

Recombinant Human Chitotriosidase/CHIT1 Protein (His Tag) | PKSH032245 | Gentaur US, UK & Europe Disrtribition

Synonyms: Chitotriosidase-1; Chitinase-1; CHIT1;CHI3;CHIT;CHITD

Active Protein: N/A

Activity: Recombinant Human Chitotriosidase-1 is produced by our Mammalian expression system and the target gene encoding Ala22-Asn466 is expressed with a 6His tag at the C-terminus.

Protein Construction: Recombinant Human Chitotriosidase-1 is produced by our Mammalian expression system and the target gene encoding Ala22-Asn466 is expressed with a 6His tag at the C-terminus.

Fusion Tag: C-6His

Species: Human

Expressed Host: Human Cells

Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at<-20°C.

Purity: > 90 % as determined by reducing SDS-PAGE.

Endotoxin: < 1.0 EU per µg as determined by the LAL method.

Stability and Storage: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Molecular Mass: 50.4 kDa

Formulation: Supplied as a 0.2 μm filtered solution of 20mM TrisHCl, 150mM NaCl, pH 7.5.

Reconstitution: Not Applicable

Background: Chitotriosidase-1 (CHIT1) is a glycoprotein that belongs to the Glycosyl Hydrolase 18 family and Chitinase class II subfamily. It is secreted by cultured macrophages and serves to degrade chitin, chitotriose and chitobiose. CHIT1 may participate in the defense against nematodes and other pathogens. It is highly expressed in the plasma of patients with Gaucher's disease type I, which can be used as diagnostic aid and to evaluate the success of treatment that brings levels back to normal. The amino acid sequence of human CHIT1 is 99%, 76%, 75% and 55% identical to that of chimpanzee, rat, mouse and fruit fly, respectively.

Research Area: immunology