Description
Recombinant Human CDO/CDON Protein (His Tag) | PKSH033720 | Gentaur US, UK & Europe Disrtribition
Synonyms: Cell adhesion molecule-related/down-regulated by oncogenes; CDON; CDO
Active Protein: N/A
Activity: Recombinant Human CDO is produced by our Mammalian expression system and the target gene encoding Asp26-Pro943 is expressed with a 6His tag at the C-terminus.
Protein Construction: Recombinant Human CDO is produced by our Mammalian expression system and the target gene encoding Asp26-Pro943 is expressed with a 6His tag at the C-terminus.
Fusion Tag: C-His
Species: Human
Expressed Host: Human Cells
Shipping: This product is provided as lyophilized powder which is shipped with ice packs.
Purity: > 85 % as determined by reducing SDS-PAGE.
Endotoxin: < 1.0 EU per μg as determined by the LAL method.
Stability and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Molecular Mass: 100.4 kDa
Formulation: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
Reconstitution: Please refer to the printed manual for detailed information.
Background: CDO (CAMrelated/down-regulatedby oncogenes) is a member of the Immunoglubulin (Ig) superfamily, Ig/Fibronectin (FN)type III repeat family of cell surface proteins. Human CDO is a type I transmembrane (TM) glycoprotein. It is synthesized as a 1287 amino acid (aa) precursorthat contains a 25 aa signal sequence, a 938 aa extracellular domain (ECD), a 21 aa TM segment and a 303 aa cytoplasmic region. The ECD contains five C2-typeIglikedomains, followed by three FN type III repeats. The ECD of human CDO is 85% aa identical to mouse CDO ECD.CDO is found on muscle precursor and neural progenitor cells of the embryo. It likely promotes muscle differentiation, and contributes to axon guidance andneuronal patterning.
Research Area: epigenetics and nuclear signal, Stem cells
