Recombinant Human CDK2AP2 Protein (E.coli, His Tag) | PKSH030818

Recombinant Human CDK2AP2 Protein (E.coli, His Tag) | PKSH030818 | Gentaur US, UK & Europe Disrtribition

Synonyms: Cyclin-dependent kinase 2-associated protein 2;CDK2-associated protein 2;DOC-1-related protein;DOC-1R;CDK2AP2;DOC1R;p14

Active Protein: N/A

Activity: A DNA sequence encoding the human CDK2AP2 (O75956) (Met 1-Thr 126) was fused with a polyhistidine tag at the C-terminus.

Protein Construction: A DNA sequence encoding the human CDK2AP2 (O75956) (Met 1-Thr 126) was fused with a polyhistidine tag at the C-terminus.

Fusion Tag: C-His

Species: Human

Expressed Host: E.coli

Shipping: This product is provided as lyophilized powder which is shipped with ice packs.

Purity: > 95 % as determined by reducing SDS-PAGE.

Endotoxin: Please contact us for more information.

Stability and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Molecular Mass: 14.5 kDa

Formulation: Lyophilized from sterile PBS, 15% glycerol, pH 7.5

Reconstitution: Please refer to the printed manual for detailed information.

Background: CDK2AP2 belongs to the CDK2AP family. Members of this family of proteins are cell-growth suppressors; associating with and influencing the biological activities of important cell cycle regulators in the S phase including monomeric non-phosphorylated cyclin-dependent kinase 2 (CDK2) and DNA polymerase alpha/primase. CDK2AP2 contains 5 distinct gt-ag introns. Transcription produces 7 different mRNAs; 6 alternatively spliced variants and 1 unspliced form. There are 2 non overlapping alternative last exons and 4 validated alternative polyadenylation sites. The mRNAs appear to differ splicing versus retention of 3 introns. CDK2AP2 plays a role in regulating self-renewal of mouse embryonic stem cells (mESC) under permissive conditions; and cell survival during differentiation of the mESC into terminally differentiated cell types.

Research Area: N/A