Description
Recombinant Human CD300a/LMIR1 Protein (Fc & His Tag) | PKSH032700 | Gentaur US, UK & Europe Disrtribition
Synonyms: CMRF35-Like Molecule 8; CLM-8; CD300 Antigen-Like Family Member A; CMRF-35-H9; CMRF35-H9; CMRF35-H; IRC1/IRC2; Immunoglobulin Superfamily Member 12; IgSF12; Inhibitory Receptor Protein 60; IRp60; NK Inhibitory Receptor; CD300a; CD300A; CMRF35H; IGSF12
Active Protein: N/A
Activity: Recombinant Human Leukocyte mono-Ig-like receptor 1 is produced by our Mammalian expression system and the target gene encoding Leu18-Gln178 is expressed with a Fc; 6His tag at the C-terminus.
Protein Construction: Recombinant Human Leukocyte mono-Ig-like receptor 1 is produced by our Mammalian expression system and the target gene encoding Leu18-Gln178 is expressed with a Fc; 6His tag at the C-terminus.
Fusion Tag: C-Fc-6His
Species: Human
Expressed Host: Human Cells
Shipping: This product is provided as lyophilized powder which is shipped with ice packs.
Purity: > 90 % as determined by reducing SDS-PAGE.
Endotoxin: < 1.0 EU per µg as determined by the LAL method.
Stability and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Molecular Mass: 45.4 kDa
Formulation: Lyophilized from a 0.2 μm filtered solution of 20mM Tris, 150mM NACl, 5% Trehalose, pH 8.0.
Reconstitution: Please refer to the printed manual for detailed information.
Background: CD300A is a single-pass type I membrane protein which belongs to the CD300 family. It contains 1 Ig-like V-type (immunoglobulin-like) domain. The CD300 family of myeloid immunoglobulin receptors includes activating (CD300b; CD300e) and inhibitory members (CD300a; CD300f); as well as molecules presenting a negative charge within their transmembrane domain (CD300c; CD300d). It is expressed not only by natural killer (NK) cells but also by T-cell subsets; B-cells; dendritic cells; mast cells; granulocytes and monocytes. CD300A is an inhibitory receptor which may contribute to the down-regulation of cytolytic activity in natural killer (NK) cells; and to the down-regulation of mast cell degranulation. CD300c is a functional immune receptor able to deliver activating signals upon ligation in RBL-2H3 mast cells.
Research Area: immunology
