Description
Recombinant Human CD28/TP44 Protein (mFc Tag) | PKSH033788 | Gentaur US, UK & Europe Disrtribition
Synonyms: CD28; CD28 antigen; CD28 molecule; T-cell-specific surface glycoprotein CD28; Tp44; TP44
Active Protein: N/A
Activity: Recombinant Human CD28 is produced by our Mammalian expressionsystem and the target gene encoding Asn19-Pro152 is expressed with a mFc tag at the C-terminus.
Protein Construction: Recombinant Human CD28 is produced by our Mammalian expressionsystem and the target gene encoding Asn19-Pro152 is expressed with a mFc tag at the C-terminus.
Fusion Tag: C-mFc
Species: Human
Expressed Host: Human Cells
Shipping: This product is provided as lyophilized powder which is shipped with ice packs.
Purity: > 95 % as determined by reducing SDS-PAGE.
Endotoxin: < 1.0 EU per μg as determined by the LAL method.
Stability and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Molecular Mass: 41.7 kDa
Formulation: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Reconstitution: Please refer to the printed manual for detailed information.
Background: T-cell-specific surface glycoprotein CD28(CD28) is a single-pass typeI membrane protein which contains one Ig-likeV-type (immunoglobulin-like)domain. It belongs to the immunoglobulin(Ig) superfamily. CD28 is one of the molecules expressed on T cells that provide co-stimulatory signals; which are required for T cell activation. CD28 co-stimulation is necessary for CD4 positive T-cell proliferation and survival; interleukin-2 production; and T-helper type-2 development. Human post-thymic regulatory T cells require CD28 co-stimulation to expand and maintain potent suppressive function in vivo. Apoptosis plays a key role in the age-related decline of CD28 expression and in immunosenescence. CD28 is the receptor for CD80(B7.1) and CD86(B7.2). When activated by Toll-like receptor ligands; the CD80 expression is upregulated in antigen presenting cells(APCs). The CD86 expression on antigen presenting cells is constitutive. CD28 is the only B7 receptor constitutively expressed on naive T cells.
Research Area: immunology, Stem cells
