Recombinant Human CD24 Protein (Ser27-Gly59, Ser44Thr)(Fc Tag) | PKSH033527

Recombinant Human CD24 Protein (Ser27-Gly59, Ser44Thr)(Fc Tag) | PKSH033527 | Gentaur US, UK & Europe Disrtribition

Synonyms: Signal transducer CD24; Small cell lung carcinoma cluster 4 antigen; CD24; CD24A;FLJ22950;FLJ43543;MGC75043

Active Protein: N/A

Activity: Recombinant Human CD24 is produced by our Mammalian expression system and the target gene encoding Ser27-Gly59(Ser44Thr) is expressed with a Fc tag at the C-terminus.

Protein Construction: Recombinant Human CD24 is produced by our Mammalian expression system and the target gene encoding Ser27-Gly59(Ser44Thr) is expressed with a Fc tag at the C-terminus.

Fusion Tag: C-Fc

Species: Human

Expressed Host: Human Cells

Shipping: This product is provided as lyophilized powder which is shipped with ice packs.

Purity: > 95 % as determined by reducing SDS-PAGE.

Endotoxin: < 1.0 EU per μg as determined by the LAL method.

Stability and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Molecular Mass: 29.8 kDa

Formulation: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Reconstitution: Please refer to the printed manual for detailed information.

Background: Signal Transducer CD24 is a heavily and variably glycosylated GPI-linked sialoprotein. Human CD24 is expressed on B lineage cells and granulocytes, on epithelial, neuronal, and muscle cells, and on a range of tumor cells. CD24 expression is regulated during lineage development and with the activation of various cell types. Antibody crosslinking of CD24 enhances the induction of apoptosis in B and T lymphocytes which contributes to negative selection and the induction of immune tolerance. CD24 on antigen presenting cells cooperates with B7 molecules in the costimulation of T cells. CD24 associates in cis with Siglec10 and with the danger-associated molecules HMGB1, HSP70, or HSP90 which are released from necrotic or damaged cells. Formation of these ternary complexes fills a protective role: the resulting Siglec10 signaling inhibits inflammatory responses that are otherwise induced by extracellular DAMPs.

Research Area: Neuroscience, Cancer, immunology, metabolism, Stem cells