Recombinant Human CCL5/RANTES Protein | PKSH500054

Recombinant Human CCL5/RANTES Protein | PKSH500054 | Gentaur US, UK & Europe Disrtribition

Synonyms: C-C motif chemokine 5, EoCP, Eosinophil chemotactic cytokine, SIS-delta, Small-inducible cytokine A5, T cell-specific protein P228, TCP228, T-cell-specific protein RANTES, D17S136E, SCYA5

Active Protein: N/A

Activity: A DNA sequence encoding the Human CCL5/RANTES Protein(P13501)(Ser24-Ser91)was expressed with a polyhistidine tag and SUMO at the N-terminus.

Protein Construction: A DNA sequence encoding the Human CCL5/RANTES Protein(P13501)(Ser24-Ser91)was expressed with a polyhistidine tag and SUMO at the N-terminus.

Fusion Tag: N-His/SUMO

Species: Human

Expressed Host: E.coli

Shipping: This product is provided as lyophilized powder which is shipped with ice packs.

Purity: > 90 % as determined by reducing SDS-PAGE.

Endotoxin: Please contact us for more information.

Stability and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Molecular Mass: 22.3 kDa

Formulation: Lyophilized from sterile PBS, pH 7.4, 5% trehalose, 5% mannitol, 0.01% tween-80.

Reconstitution: Please refer to the printed manual for detailed information.

Background: Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1-68) and RANTES(3-68) and is generated by an unidentified enzyme associated with monocytes and neutrophils

Research Area: Immunology, Cardiovascular