Recombinant Human Cathepsin S/CTSS Protein (His Tag)(Active) | PKSH033736

Recombinant Human Cathepsin S/CTSS Protein (His Tag)(Active) | PKSH033736 | Gentaur US, UK & Europe Disrtribition

Synonyms: Cathepsin S;CTSS;CTSS;MGC3886

Active Protein: Active protein

Activity: Recombinant Human Cathepsin S is produced by our Mammalian expression system and the target geneencoding Gln17-Ile331(pro)&Ser109-Ile331&Gln17-Ser109(Propeptide) is expressed with a 6His tag atthe C-terminus.

Protein Construction: Recombinant Human Cathepsin S is produced by our Mammalian expression system and the target geneencoding Gln17-Ile331(pro)&Ser109-Ile331&Gln17-Ser109(Propeptide) is expressed with a 6His tag atthe C-terminus.

Fusion Tag: C-His

Species: Human

Expressed Host: Human Cells

Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at<-20°C.

Purity: > 90 % as determined by reducing SDS-PAGE.

Endotoxin: < 1.0 EU per μg as determined by the LAL method.

Stability and Storage: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Molecular Mass: 36.9&25&11.2 kDa

Formulation: Supplied as a 0.2 μm filtered solution of 20mM MES, 150mM NaCl, 10% Glycerol, pH 5.5.

Reconstitution: Not Applicable

Background: Cathepsin S is a lysosomal enzyme that belongs to the papain family of cysteine proteases. This protein is expressed by antigen presenting cells including macrophages, B-lymphocytes, dendritic cells and microglia. Moreover, cathepsin S is expressed in some epithelial cells. Compared with the abundant cathepsins B, LandH, cathepsin S shows a restricted tissue distribution, with highest levels in spleen, heart, and lung. In addition, evidences indicated that cathepsin S generates A beta from amyloidogenic fragments of beta APP in the endosomal/lysosomal compartment, and is implicated in the pathogenesis of Alzheimer’s disease(AD) and Down Syndrome (DS).

Research Area: Tags & Cell Markers, Cell biology, immunology