Recombinant Human Carboxypeptidase E/CPE Protein (His Tag) | PKSH032173

Recombinant Human Carboxypeptidase E/CPE Protein (His Tag) | PKSH032173 | Gentaur US, UK & Europe Disrtribition

Synonyms: Carboxypeptidase E(CPE for short); Carboxypeptidase H; Enkephalin convertase; Prohormone-processing carboxypeptidase

Active Protein: N/A

Activity: Recombinant Human Carboxypeptidase E is produced by our Mammalian expression system and the target gene encoding Arg42-Ser453 is expressed with a 6His tag at the C-terminus.

Protein Construction: Recombinant Human Carboxypeptidase E is produced by our Mammalian expression system and the target gene encoding Arg42-Ser453 is expressed with a 6His tag at the C-terminus.

Fusion Tag: C-6His

Species: Human

Expressed Host: Human Cells

Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at<-20°C.

Purity: > 95 % as determined by reducing SDS-PAGE.

Endotoxin: < 1.0 EU per µg as determined by the LAL method.

Stability and Storage: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Molecular Mass: 47.1 kDa

Formulation: Supplied as a 0.2 μm filtered solution of 20mM TrisHCl, 150mM NaCl, 1mM ZnCl2, 10%Glycerol, pH7.5.

Reconstitution: Not Applicable

Background: The active form of CPE cleaves C-terminal amino acid residues of the peptide, and is thus involved in the biosynthesis of peptide hormones and neurotransmitters including insulin, enkephalin, etc. It is thought that membrane-associated CPE acts as a sorting receptor for targeting regulated secretory proteins which are mostly prohormones and neuropeptides in the trans-Golgi network of the pituitary and in secretory granules into the secretory pathway. Defects in this protein are implicated in type II diabetes due to impaired glucose clearance and insulin resistance.

Research Area: Signal Transduction, Neuroscience, Cancer, metabolism,