Recombinant Human CALCB Protein (aa 1-118, Fc Tag) | PKSH030665

Recombinant Human CALCB Protein (aa 1-118, Fc Tag) | PKSH030665 | Gentaur US, UK & Europe Disrtribition

Synonyms: Calcitonin gene-related peptide 2; CALC2; Beta-type CGRP; Calcitonin gene-related peptide II; CALCB

Active Protein: N/A

Activity: A DNA sequence encoding the human CALCB (P10092) (Met1-Phe118) was fused with Fc region of mouse IgG at the C-terminus.

Protein Construction: A DNA sequence encoding the human CALCB (P10092) (Met1-Phe118) was fused with Fc region of mouse IgG at the C-terminus.

Fusion Tag: C-Fc

Species: Human

Expressed Host: HEK293 Cells

Shipping: This product is provided as lyophilized powder which is shipped with ice packs.

Purity: > 95 % as determined by reducing SDS-PAGE.

Endotoxin: < 1.0 EU per µg of the protein as determined by the LAL method.

Stability and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Molecular Mass: 36.2 kDa

Formulation: Lyophilized from sterile PBS, pH 7.4

Reconstitution: Please refer to the printed manual for detailed information.

Background: CALCB; also known as CGPR and calcitonin 2; belongs to the calcitonin family. CALCB is a calcitonin (CT) peptide which may play a role in the mediation of human inflammatory diseases. It is highly expressed in the skin; blood; and cerebrospinal fluid. CGRP immunolabeling (IL) was detected in epidermal keratinocytes at levels that were especially high and widespread in the skin of humans from locations afflicted with postherpetic neuralgia (PHN) and complex region pain syndrome type 1 (CRPS); of monkeys infected with simian immunodeficiency virus; and of rats subjected to L5/L6 spinal nerve ligation; sciatic nerve chronic constriction; and subcutaneous injection of complete Freund's adjuvant. Increased CGRP-IL was also detected in epidermal keratinocytes of transgenic mice with keratin-14 promoter driven overexpression of noggin; an antagonist to BMP-4 signaling. CGPR dilates a variety of vessels including the coronary; cerebral and systemic vasculature.

Research Area: Cardiovascular, Neuroscience