Recombinant Human BRCA2 Protein (His Tag) | PKSH500011

Recombinant Human BRCA2 Protein (His Tag) | PKSH500011 | Gentaur US, UK & Europe Disrtribition

Synonyms: BRCA 2, BRCA1/BRCA2 containing complex subunit 2, Brca2, BRCA2, DNA repair associated, BRCA2, BRCC 2, BRCC2, Breast and ovarian cancer susceptibility gene early onset, breast and ovarian cancer susceptibility protein 2, Breast cancer 2 early onset, Breast Cancer 2 tumor suppressor, Breast cancer susceptibility protein BRCA2, Breast cancer type 2 susceptibility protein, BROVCA2, FACD, FAD 1, FAD, FAD1, FANCB, FANCD 1, FANCD, FANCD1, FANCD1 gene, Fanconi anemia complementation group D1, Fanconi anemia group D1 protein, GLM3, mutant BRCA2, OTTHUMP00000018803, OTTHUMP00000042401, PNCA2, XRCC11

Active Protein: Active protein

Activity: A DNA sequence encoding the Human BRCA2 (P51587-1) (Thr2350-Val2545) was expressed with a polyhistidine tag at the N-terminus.

Protein Construction: A DNA sequence encoding the Human BRCA2 (P51587-1) (Thr2350-Val2545) was expressed with a polyhistidine tag at the N-terminus.

Fusion Tag: N-His

Species: Human

Expressed Host: E.coli

Shipping: This product is provided as lyophilized powder which is shipped with ice packs.

Purity: > 85 % as determined by reducing SDS-PAGE.

Endotoxin: Please contact us for more information.

Stability and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Molecular Mass: 22.1kDa

Formulation: Lyophilized from sterile PBS, pH 7.4

Reconstitution: Please refer to the printed manual for detailed information.

Background: Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele.

Research Area: N/A