Description
Recombinant Human BMPR2 Protein (Fc & His Tag) | PKSH032121 | Gentaur US, UK & Europe Disrtribition
Synonyms: BMPR-II;BMPR3;BMR2;BRK-3;POVD1;PPH1;T-ALK
Active Protein: N/A
Activity: Recombinant Human Bone morphogenetic protein receptor type IIA is produced by our Mammalian expression system and the target gene encoding Ser27-Ile151 is expressed with a Fc, 6His tag at the C-terminus.
Protein Construction: Recombinant Human Bone morphogenetic protein receptor type IIA is produced by our Mammalian expression system and the target gene encoding Ser27-Ile151 is expressed with a Fc, 6His tag at the C-terminus.
Fusion Tag: C-Fc-6His
Species: Human
Expressed Host: Human Cells
Shipping: This product is provided as lyophilized powder which is shipped with ice packs.
Purity: > 95 % as determined by reducing SDS-PAGE.
Endotoxin: < 1.0 EU per µg as determined by the LAL method.
Stability and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Molecular Mass: 41.9 kDa
Formulation: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH7.4.
Reconstitution: Please refer to the printed manual for detailed information.
Background: Bone Morphogenetic Protein Receptor II (BMPR-II) is a Type II Serine/Threonine Kinase that mediates cellular responses to BMPs. BMPR-II is characterized by lacking of a GS domain, and presence of a C-terminal extension typical of type II receptors. BMPRII binds BMP2, BMP4 and BMP7 weakly in the absence of type I receptor, and the binding can be facilitated by the presence of the type I receptor, including BMPR-IA/Brk1, BMPR-IB, and ActR-I. BMPR-II plays a key role in cell growth. Defects in BMPR-II have been linked to primary pulmonary hypertension. Human and mouse BMPR-II are highly conserved and share 97 % amino acid sequence identity.
Research Area: Signal Transduction, Cardiovascular, Stem cells
