Recombinant Human BCL6/B-cell CLL lymphoma 6 Protein (aa 1-150, His & Trx Tag) | PKSH030910

Recombinant Human BCL6/B-cell CLL lymphoma 6 Protein (aa 1-150, His & Trx Tag) | PKSH030910 | Gentaur US, UK & Europe Disrtribition

Synonyms: BCL5;BCL6A;LAZ3;ZBTB27;ZNF51

Active Protein: N/A

Activity: A DNA sequence encoding the human BCL6 (P41182) N-terminal fragment (Met 1-Met 150) was fused with a Trx and a polyhistidine tag at the N-terminus.

Protein Construction: A DNA sequence encoding the human BCL6 (P41182) N-terminal fragment (Met 1-Met 150) was fused with a Trx and a polyhistidine tag at the N-terminus.

Fusion Tag: N-His & Trx

Species: Human

Expressed Host: E.coli

Shipping: This product is provided as lyophilized powder which is shipped with ice packs.

Purity: > 92 % as determined by reducing SDS-PAGE.

Endotoxin: Please contact us for more information.

Stability and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Molecular Mass: 34.2 kDa

Formulation: Lyophilized from sterile 20mM Tris, 10% glycerol, pH 8.0

Reconstitution: Please refer to the printed manual for detailed information.

Background: The protein encoded by this gene is an evolutionarily conserved 95-kDa protein containing six C-terminal zinc-finger motifs and an N-terminal POZ domain. It has been reported that BCL-6 is present in DNA-binding complexes in nuclear extracts from various B-cell lines. There are many relationships between non-Hodgkin's lymphoma, diffuse large cell lymphoma and BCL6’s translocations. BCL6 can repress transcription from promoters linked to its DNA target sequence and this activity is dependent upon specific DNA-binding and the presence of an intact N-terminal half of the protein.

Research Area: Cancer, epigenetics and nuclear signal