Description
Recombinant Human BCL2L1/Bcl-XL Protein (His Tag) | PKSH033757 | Gentaur US, UK & Europe Disrtribition
Synonyms: Bcl-2-Like Protein 1; Bcl2-L-1; Apoptosis Regulator Bcl-X; Bcl-X;bcl-xL;BCL-XL/S;bcl-xS;BCL2L;BCLX;BCLXL;BCLXS;PPP1R52
Active Protein: N/A
Activity: Recombinant Human BCL2L1 is produced by our E.coli expression system and the target gene encoding Met1-Arg212 is expressed with a 6His tag at the C-terminus.
Protein Construction: Recombinant Human BCL2L1 is produced by our E.coli expression system and the target gene encoding Met1-Arg212 is expressed with a 6His tag at the C-terminus.
Fusion Tag: C-His
Species: Human
Expressed Host: E.coli
Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at<-20°C.
Purity: > 95 % as determined by reducing SDS-PAGE.
Endotoxin: < 1.0 EU per μg as determined by the LAL method.
Stability and Storage: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Molecular Mass: 24.85 kDa
Formulation: Supplied as a 0.2 μm filtered solution of 20mM HEPES, 50mM KCl, 20% Glycerol, pH 7.5.
Reconstitution: Not Applicable
Background: Bcl-2-Like Protein 1 (BCL2L1) is a member of the Bcl-2 family. BCL2L1 is expressed at high levels in cells that undergo a high rate of turnover, such as developing lymphocytes. BCL2L1 is a mitochondrial membrane protein. BCL2L1 contains four motifs, BH1, BH2 and BH4. The BH4 motif is required for anti-apoptotic activity. The BH1 and BH2 motifs are required for both heterodimerization with other Bcl-2 family members and for repression of cell death. BCL2L1 regulates cell death by blocking the voltage-dependent anion channnel (VDAC) and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. In addition, BCL2L1 promotes apoptosis.
Research Area: Signal Transduction, Cell biology, Cancer, metabolism,
