Description
Recombinant Human BCAS2/DAM1 Protein (His & T7 Tag) | PKSH032111 | Gentaur US, UK & Europe Disrtribition
Synonyms: Pre-mRNA-Splicing Factor SPF27; Breast Carcinoma-Amplified Sequence 2; DNA Amplified in Mammary Carcinoma 1 Protein; Spliceosome-Associated Protein SPF 27; BCAS2; DAM1
Active Protein: N/A
Activity: Recombinant Human Breast Carcinoma-Amplified Sequence 2 is produced by our E.coli expression system and the target gene encoding Ala2-Phe225 is expressed with a T7 tag at the N-terminus, 6His tag at the C-terminus.
Protein Construction: Recombinant Human Breast Carcinoma-Amplified Sequence 2 is produced by our E.coli expression system and the target gene encoding Ala2-Phe225 is expressed with a T7 tag at the N-terminus, 6His tag at the C-terminus.
Fusion Tag: C-6His, N-T7
Species: Human
Expressed Host: E.coli
Shipping: This product is provided as lyophilized powder which is shipped with ice packs.
Purity: > 90 % as determined by reducing SDS-PAGE.
Endotoxin: < 1.0 EU per µg as determined by the LAL method.
Stability and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Molecular Mass: 28.6 kDa
Formulation: Lyophilized from a 0.2 μm filtered solution of 20mM TrisHCl, 200mM NaCl, 2mM DTT, pH 8.0.
Reconstitution: Please refer to the printed manual for detailed information.
Background: Breast Carcinoma-Amplified Sequence 2 (BCAS2) is a member of the SPF27 family. BCAS2 is a nuclear protein and widely expressed in many rtissues. BCAS2 is identified as being overexpressed in various breast cancer cell lines. BCAS2 is a component of the spliceosome, taking part in the removal of introns from mRNA precursors. BCAS2 interacts with estrogen receptor alpha and beta, thyroid hormone receptor beta, peroxisome proliferator-activated receptor gamma. BCAS2 functions as an ER co-activator and is capable of enhancing ER-mediated transcription.
Research Area: Tags & Cell Markers, epigenetics and nuclear signal
