Description
Recombinant Human ATG5 Protein | PKSH032101 | Gentaur US, UK & Europe Disrtribition
Synonyms: Autophagy protein 5; APG5-like; Apoptosis-specific protein; APG5L; ASP; ATG5;
Active Protein: N/A
Activity: Recombinant Human Autophagy Related 5 Homolog is produced by our E.coli expression system and the target gene encoding Met1-Asp275 is expressed.
Protein Construction: Recombinant Human Autophagy Related 5 Homolog is produced by our E.coli expression system and the target gene encoding Met1-Asp275 is expressed.
Fusion Tag:
Species: Human
Expressed Host: E.coli
Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at<-20°C.
Purity: > 90 % as determined by reducing SDS-PAGE.
Endotoxin: < 1.0 EU per µg as determined by the LAL method.
Stability and Storage: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Molecular Mass: 32.4 kDa
Formulation: Supplied as a 0.2 μm filtered solution of 20mM Tris, 0.2M NaCl, 1mM DTT, 40%glycerol, pH 8.0 .
Reconstitution: Not Applicable
Background: ATG5 is an E2 ubiquitin ligase which is necessary for autophagy. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity, dramatically highly expressed in apoptotic cells. It is activated by ATG7, conjugates to ATG12 and associates with isolation membrane to form cup-shaped isolation membrane and autophagosome. The conjugate complex detaches from the membrane immediately before or after autophagosome formation is completed. ATG5 plays an important role in the apoptotic process, possibly within the modified cytoskeleton.
Research Area: Signal Transduction, Cell biology, Cardiovascular, Cancer, metabolism,
